Key Publications

1] Stephens AD,  Zacharopoulou M, Moons R,  Fusco G, Seetaloo N, Chiki A, Hooper PJ, Mela I, Lashuel HA,  Philips JJ,  De Simone A, Sobott FD,  Kaminski Schierle GS, Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity, Nat Commun 11, 2820 (2020)

2] Lautenschläger J.,  Wagner-Valladolid S., Stephens AD., Fernández-Villegas A., Hockings C., Mishra A., Manton J.D., Fantham M.J., Lu M., Rees E.J., Kaminski1 C.F., and Kaminski Schierle G.S., Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β 1-42 pathologies, J. Biol. Chem. jbc.RA119.011650 (2020)

3] Hockings C.,  Poudel C., Feeney K.A., Novo C.L., Hamouda M.S., Mela I.,  Fernandez-Antoran D.,  Vallejo-Ramirez P.P.,  Rugg-Gunn P.J.,  Chalut K.,  Kaminski C.F.,  Kaminski-Schierle G.S., Illuminating chromatin compaction in live cells and fixed tissues using SiR-DNA fluorescence lifetime, (Preprint), bioRXiv

4] Stephens AD, Kaminski Schierle GS, The role of water in amyloid aggregation kinetics., Curr Opin Struct Biol. 2019 Jul 9;58:115-123.

5] Lautenschläger J, Kaminski Schierle GS., Mitochondrial degradation of amyloidogenic proteins — A new perspective for neurodegenerative diseases, Prog Neurobiol. 2019 Oct;181:101660.

6] Huang C, Wagner-Valladolid S, Stephens AD, Jung R, Poudel C, Sinnige T, Lechler MC, Schlörit N, Lu M, Laine RF, Michel CH, Vendruscolo M, Kaminski CF, Kaminski Schierle GS, David DC., Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans., eLife 2019; 8: e43059,.

7] Laine RF, Sinnige T, Ma KY, Haack AJ, Poudel C, Gaida P, Curry N, Perni M, Nollen EAA, Dobson CM, Vendruscolo M, Kaminski Schierle GS, Kaminski CF., Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans., ACS Chem Biol. 2019 Jul 19;14(7):1628-1636

8] Lu M, Banetta L, Young LJ, Smith EJ, Bates GP, Zaccone A, Kaminski Schierle GS, Tunnacliffe A, Kaminski CF. “Live-cell super-resolution microscopy reveals a primary role for diffusion in polyglutamine-driven aggresome assembly” J Biol Chem, (2019), 294(1):257-268. doi: 10.1074/jbc.RA118.003500.

9] Stephens AD, Zacharopoulou M, Kaminski Schierle GS. The Cellular Environment Affects Monomeric α-Synuclein Structure” Trends Biochem Sci. (2018). pii: S0968-0004(18)30246-9. doi: 10.1016/j.tibs.2018.11.005. 

10] Lu M, Williamson N, Mishra A, Michel CH, Kaminski CF, Tunnacliffe A, Kaminski Schierle GS “Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multi-parametric imaging” J Biol Chem, (2018) Nov 30. doi: 10.1074/jbc.RA118.004511

11] Stephens A D, Nespovitaya N, Zacharopoulou M, Kaminski C F, Phillips J J, Kaminski Schierle G S “Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing” Analytical Chemistry, (2018), 90 (11), 6975-6983 doi:10.1021/acs.analchem.8b01264

12] Qamar S, Wang G, Randle S J, Simone Ruggeri F, Varela J A, Lin J Q, Phillips E C, Miyashita A, Williams D, Ströhl F, Meadows W, Ferry R, Dardov V J, Tartaglia G G, Farrer L A, Kaminski Schierle G S, Kaminski C F, Holt C E, Fraser P E, Schmitt-Ulms G, Klenerman D, Knowles T, Vendruscolo M, St George-Hyslop P, "FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions", Cell, (2018), 173, (3), 720-734.  doi.org/10.1016/j.cell.2018.03.056  | summary

13] Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M, Pinotsi D, Zago W, Fraser P, Tandon A, St George-Hyslop P, Rees E, Phillips JJ, De Simone A, Kaminski CF, Kaminski Schierle GS, "C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction", Nature Communications, (2018), 9 712.  doi:10.1038/s41467-018-03111-4  | summary

14] Lautenschläger J, Kaminski CF, Kaminski Schierle GS, "α-Synuclein – Regulator of Exocytosis, Endocytosis, or Both?", Trends in Cell Biology (2017).  doi:10.1016/j.tcb.2017.02.002

Molecular Neuroscience Group (2019)